BDBM127767 US10251889, Example 140::US10758542, Example 140::US8791123, 140::US9782415, Example 140::US9796724, Example 140

SMILES COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CC[C@H](O)CC3)c2n1

InChI Key InChIKey=WRXZQYJJPXFOIB-HFLHWUEFSA-N

Data  32 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 127767   

TargetTyrosine-protein kinase JAK1 [866-1154](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM127767(US10251889, Example 140 | US10758542, Example 140 ...)
Affinity DataIC50:  546nMAssay Description:Compounds of Formula I were screened for their ability to inhibit Jak1 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1 [866-1154](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM127767(US10251889, Example 140 | US10758542, Example 140 ...)
Affinity DataIC50:  546nMAssay Description:Jak1: Compounds of Formula I were screened for their ability to inhibit Jak1 using the general enzyme inhibition assay method, in which the assay mix...More data for this Ligand-Target Pair
In DepthDetails US Patent